The problem with any premises is that you need to make good sales to cover the cost of rent/rates, otherwise the business is sure to fail. And the best premises for the business, for passing trade, etc, will probably also be in an expensive location.

It is worth considering why you need premises? If you do a lot of business mail order, then perhaps you can work out of a small back street location that won't cost you so much? However, I think an on-line store is great if you want to supplement local shop sales, or go for 100% e-commerce.

But selling on the Internet is not without its problems either. You will need to constantly review how to attract the maximum website traffic to give yourself the chance of the highest level of sales.